Tetrahedron letters

A practical method for the preparation of α′-chloroketones of N-carbamate protected-α-aminoacids

P Chen, PTW Cheng, SH Spergel, R Zahler, X Wang…

Index: Chen, Ping; Cheng, Peter T. W.; Spergel, Steven H.; Zahler, Robert; Wang, Xuebao; Thottathil, John; Barrish, Joel C.; Polniaszek, Richard P. Tetrahedron Letters, 1997 , vol. 38, # 18 p. 3175 - 3178

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Citation Number: 59

Abstract

A practical method for the preparation of α-N-BOC-epoxides from protected amino acid esters based on the Kowalski homologation reaction is described. This procedure can be readily performed on a large scale without the use of hazardous reagents and has allowed preparation of epoxides 3 in multi-kilogram quantities.

~74%

~83%

~84%

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