Development of a new type of protease inhibitors, efficacious against FIV and HIV variants

…, GM Morris, AL Wong, AJ Olson, JH Elder…

Index: Lee, Taekyu; Le, Van-Duc; Lim, Dongyeol; Lin, Ying-Chuan; Morris, Garrett M.; Wong, Andrew L.; Olson, Arthur J.; Elder, John H.; Wong, Chi-Huey Journal of the American Chemical Society, 1999 , vol. 121, # 6 p. 1145 - 1155

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Citation Number: 68

Abstract

Based on the structural analysis of FIV protease and drug-resistant HIV proteases and molecular modeling, a new type of inhibitors with a small P3 residue has been developed. These inhibitors are effective against HIV and its drug-resistant mutants, as well as SIV and FIV. Modification of existing HIV protease inhibitors by reducing the size of the P3 residue has the same effect. This finding provides a new strategy for the development of HIV ...