European journal of medicinal chemistry

Synthesis and antidepressant activity of arylalkanol-piperidine derivatives as triple reuptake inhibitors

YY Zheng, L Guo, XC Zhen, JQ Li

Index: Zheng, Yong-Yong; Guo, Lin; Zhen, Xue-Chu; Li, Jian-Qi European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 123 - 136

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Citation Number: 8

Abstract

A series of arylalkanol-piperidine derivatives was synthesized, and their triple reuptake inhibition and in vivo activities have been evaluated. Among them, compounds 2a, 2j, 2k, 2m and 2n exhibited high potency for 5-HT, NA and DA transporters. Optimized compounds 2j and 2m showed significant reduction of immobility time compared to that of vehicle in the mouse tail suspension test (TST) test at doses ranging from 10 to 50 mg/kg po, and were ...

 Related Synthetic Route
Propionic anhydride Structure

123-62-6

Propionic anhydride

1,2-Dichlorobenzene Structure

95-50-1

1,2-Dichlorobenzene

~79%

3-Chloro-1-(4-chlorophenyl)-1-propanone Structure

6582-42-9

3-Chloro-1-(4-c...

Fluorobenzene Structure

462-06-6

Fluorobenzene

~%

2′-Bromo-3-fluoropropiophenone Structure

92821-83-5

2′-Bromo-3-fluo...

2-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)-1-(4-methoxyphenyl)propan-1-one hydrochloride Structure

1394148-24-3

2-(4-benzyl-5,6...

~%

2-(4-benzyl-3,6-dihydro-2H-pyridin-1-yl)-1-(4-methoxyphenyl)propan-1-ol Structure

35133-59-6

2-(4-benzyl-3,6...

N/A Structure

1394204-84-2

N/A

~%

2-(4-benzyl-3,6-dihydro-2H-pyridin-1-yl)-1-(4-methoxyphenyl)propan-1-ol Structure

35133-59-6

2-(4-benzyl-3,6...

2-bromo-1-(4-methoxyphenyl)propan-1-one Structure

21086-33-9

2-bromo-1-(4-me...

~%

2-(4-benzyl-3,6-dihydro-2H-pyridin-1-yl)-1-(4-methoxyphenyl)propan-1-ol Structure

35133-59-6

2-(4-benzyl-3,6...

Anisole Structure

100-66-3

Anisole

~%

2-(4-benzyl-3,6-dihydro-2H-pyridin-1-yl)-1-(4-methoxyphenyl)propan-1-ol Structure

35133-59-6

2-(4-benzyl-3,6...

4'-Methoxypropiophenone Structure

121-97-1

4'-Methoxypropi...

~%

2-(4-benzyl-3,6-dihydro-2H-pyridin-1-yl)-1-(4-methoxyphenyl)propan-1-ol Structure

35133-59-6

2-(4-benzyl-3,6...

1,2-Dichlorobenzene Structure

95-50-1

1,2-Dichlorobenzene

~%

2-bromo-1-(3,4-dichlorophenyl)propan-1-one Structure

87427-61-0

2-bromo-1-(3,4-...

Propionic anhydride Structure

123-62-6

Propionic anhydride

Thianaphthene Structure

95-15-8

Thianaphthene

~60%

1-Propanone,1-benzo[b]thien-3-yl- Structure

19492-96-7

1-Propanone,1-b...

1,2-Dichlorobenzene Structure

95-50-1

1,2-Dichlorobenzene

3-Chloropropanoyl chloride Structure

625-36-5

3-Chloropropano...

~86%

3-chloro-1-(3,4-dichlorophenyl)propan-1-one Structure

35857-66-0

3-chloro-1-(3,4...

Fluorobenzene Structure

462-06-6

Fluorobenzene

Propionic anhydride Structure

123-62-6

Propionic anhydride

~%

3'-Fluoropropiophenone Structure

455-67-4

3'-Fluoropropio...


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