Tetrahedron letters

The condensation reaction between isocyanates and carboxylic acids. A practical synthesis of substituted amides and anilides.

IS Blagbrough, NE Mackenzie, C Ortiz, AI Scott

Index: Blagbrough, Ian S.; Mackenzie, Neil E.; Ortiz, Claudio; Scott, A. Ian Tetrahedron Letters, 1986 , vol. 27, # 11 p. 1251 - 1254

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Citation Number: 50

Abstract

Abstract Addition of a carboxylic acid to an isocyanate initially yields the mixed acid anhydride, decarboxylation of which leads to the N-substituted amide. The conversion of acid into amide was shown to proceed similarly for both aliphatic and aromatic carboxylic acids with a range of substituted isocyanates.