Tetrahedron

An expedient, regioselective synthesis of novel 2-alkylamino-and 2-alkylthiothiazolo [5, 4-e]-and-[4, 5-g] indazoles and their anticancer potential

M Chakrabarty, T Kundu, S Arima, Y Harigaya

Index: Chakrabarty, Manas; Kundu, Taraknath; Arima, Shiho; Harigaya, Yoshihiro Tetrahedron, 2008 , vol. 64, # 28 p. 6711 - 6723

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Citation Number: 16

Abstract

Several novel 2-alkylamino-and 2-alkylthiothiazolo [5, 4-e]-and-[4, 5-g] indazoles and their 6- alkyl and 8-alkyl derivatives have been synthesised in high overall yields starting from 5- nitro and 6-nitroindazoles in a three-step route involving the regioselective cyclisation of thioureidoindazoles and indazolyl dithiocarbamates as the key steps. Some assorted thiazoloindazoles have been screened for anticancer properties, which demonstrated the ...