Tetrahedron

A method for the regioselective synthesis of 1-alkyl-1H-indazoles

HJ Liu, SF Hung, CL Chen, MH Lin

Index: Liu, Han-Jun; Hung, Shiang-Fu; Chen, Chuan-Lin; Lin, Mei-Huey Tetrahedron, 2013 , vol. 69, # 19 p. 3907 - 3912

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Citation Number: 7

Abstract

A method for the regioselective synthesis of 3-unsubstituted 1-alkyl-1H-indazoles, starting with 2-halobenzonitriles and N-alkylhydrazines, is described. The two-step reaction pathway proceeds through the intermediacy of 1-alkyl-3-amino-1H-indazoles followed by reductive deamination.

~90%

~94%

~95%

~80%

~83%

~88%

~82%

~94%

~86%

~90%

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