Pentacyclic triterpenes. Part 2: Synthesis and biological evaluation of maslinic acid derivatives as glycogen phosphorylase inhibitors

X Wen, P Zhang, J Liu, L Zhang, X Wu, P Ni…

Index: Wen, Xiaoan; Zhang, Pu; Liu, Jun; Zhang, Luyong; Wu, Xiaoming; Ni, Peizhou; Sun, Hongbin Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 3 p. 722 - 726

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Citation Number: 98

Abstract

The synthesis of a series of maslinic acid derivatives is described and their effect on rabbit muscle glycogen phosphorylase a evaluated. Within this series of compounds, 15 (IC 50 = 7 μM) is the most potent GPa inhibitor. SAR of the maslinic acid derivatives are discussed. ... The synthesis of a series of maslinic acid derivatives is described and their effect on rabbit muscle glycogen phosphorylase a evaluated. Within this series of compounds, 15 (IC 50 = 7 μM) is the ...