The Copper??Catalyzed C??3??Formylation of Indole C H Bonds using Tertiary Amines and Molecular Oxygen

…, B Liu, D Liu, S Liu, J Cheng

Index: Chen, Jianbin; Liu, Bin; Liu, Dongfang; Liu, Shan; Cheng, Jiang Advanced Synthesis and Catalysis, 2012 , vol. 354, # 13 p. 2438 - 2442

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Citation Number: 40

Abstract

Abstract A copper-catalyzed formylation reaction has been developed by employing oxygen (O 2) as the clean oxidant. The C [BOND] H bonds of indoles were C-3-formylated by tetramethylethylenediamine (TMEDA) and water (H 2 O; in situ formed and external added water) as the carbonyl source in moderate to good yields with good functional group tolerance. Thus, it represents a facile procedure leading to 3-formylindoles.