2-Methylquinazolin-4-ol

Modify Date: 2025-08-21 13:45:19

2-Methylquinazolin-4-ol structure	Common Name	2-Methylquinazolin-4-ol
	CAS Number	1769-24-0	Molecular Weight	160.17300
	Density	1.26 g/cm3	Boiling Point	305.4ºC at 760 mmHg
	Molecular Formula	C₉H₈N₂O	Melting Point	231-233ºC(lit.)
	MSDS	N/A	Flash Point	138.5ºC

Use of 2-Methylquinazolin-4-ol

2-Methylquinazolin-4-ol is a potent competitive poly(ADP-ribose) synthetase inhibitor, with a Ki of 1.1 μM. 2-Methylquinazolin-4-ol mammalian aspartate transcarbamylase (ATCase) inhibitor, with 0.20 mM[1][2].

Name	2-Methylquinazolin-4-ol
Synonym	More Synonyms

Description	2-Methylquinazolin-4-ol is a potent competitive poly(ADP-ribose) synthetase inhibitor, with a Ki of 1.1 μM. 2-Methylquinazolin-4-ol mammalian aspartate transcarbamylase (ATCase) inhibitor, with 0.20 mM[1][2].
Related Catalog	Signaling Pathways >> Epigenetics >> PARP Research Areas >> Others Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
In Vitro	2-Methylquinazolin-4-ol inhibits ATCase in a concentration-dependent manner[1].
In Vivo	2-Methylquinazolin-4-ol (0.2-1 mg; i.g.; for two days) inhibits ATCase in a dosedependent manner in vivo[2]. Animal Model: Mice[2] Dosage: 0.2 mg, 0.4 mg, 0.6 mg, 0.8 mg, 1 mg Administration: Oral gavage, for two days Result: Showed an inhibitory effect upon ATCase.
References	[1]. S Yoshida, et al. Production of 2-methyl-4[3H]-quinazolinone, an inhibitor of poly(ADP-ribose) synthetase, by bacterium. J Antibiot (Tokyo). 1991 Jan;44(1):111-2. [2]. Mahmoud Balbaa, et al. Inhibition of mammalian aspartate transcarbamylase by quinazolinone derivatives. J Enzyme Inhib Med Chem. 2008 Aug;23(4):483-92.

Density	1.26 g/cm3
Boiling Point	305.4ºC at 760 mmHg
Melting Point	231-233ºC(lit.)
Molecular Formula	C₉H₈N₂O
Molecular Weight	160.17300
Flash Point	138.5ºC
Exact Mass	160.06400
PSA	45.75000
LogP	1.23150

2-Methylquinazolin-4-ol MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VA3677000

CHEMICAL NAME :: 4(3H)-Quinazolinone, 2-methyl-

CAS REGISTRY NUMBER :: 1769-24-0

LAST UPDATED :: 199609

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C9-H8-N2-O

MOLECULAR WEIGHT :: 160.19

WISWESSER LINE NOTATION :: T66 BVM ENJ D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 859 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,1204,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 592 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,1204,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - smooth muscle relaxant (mechanism undefined, spasmolytic) Behavioral - tremor Behavioral - muscle weakness

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 7,626,1973

Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26;S37/S39
WGK Germany	3
RTECS	VA3677000
HS Code	2933990090

Precursor 9
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CAS#:108-24-7 Ethanoic anhydride
DownStream 10
CAS#:104968-03-8 4-Oxo-3,4-dihyd... CAS#:1769-25-1 2,3-Dimethyl-3H... CAS#:182956-26-9 6-methyl-2,3-di... CAS#:19062-51-2 2-(bromomethyl)...
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HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

EINECS 217-189-2

MFCD00006887

2-methyl-4(3h)-quinazolinone

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 2-Methylquinazolin-4-ol
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 2-Methylquinazolin-4-ol
Price: ￥1128.0/5g
Purity: 98.0%
Delivery: 2 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: 2-Methylquinazolin-4-ol
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-Methyl-4(3H)-quinazolinone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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