Synthesis of Biaryls by Pd??Catalyzed Decarboxylative Homo??and Heterocoupling of Substituted Benzoic Acids

K Xie, S Wang, Z Yang, J Liu, A Wang…

Index: Xie, Kai; Wang, Sizhuo; Yang, Zhiyong; Liu, Jidan; Wang, Anwei; Li, Xiujian; Tan, Ze; Guo, Can-Cheng; Deng, Wei European Journal of Organic Chemistry, 2011 , # 29 p. 5787 - 5790

Full Text: HTML

Citation Number: 2

Abstract

Abstract By carefully choosing the right substrate ratio, catalyst combination, and base, symmetrical and unsymmetrical biaryls can be readily synthesized through the Pd-catalyzed decarboxylative homo-and heterocoupling of substituted benzoic acids. The reaction gave the desired products in 40–90% yield and is compatible with 2-nitro-, 2-methoxy-, 2-fluoro-, and 2-chloro-substituted benzoic acids.