The quantitative nucleophilic reactivity of alkyl and dialkylimidazo [1, 2-a] pyridines towards methyl iodide is described. In the series of monomethyl derivatives the 7-methyl compound is the most activated and the 8-methyl compound the most deactivated. The effects of two alkyl substituants on the rate of alkylation are additive in the absence of intramolecular steric interaction. On the contrary a deactivation of N1 is observed for the peri disubstituted ...
![Imidazo[1,2-a]pyridine Structure](https://image.chemsrc.com/caspic/372/274-76-0.png)
![Imidazo[1,2-a]pyridinium,1-methyl-, iodide (1:1) Structure](https://image.chemsrc.com/caspic/299/15562-25-1.png)