Synthesis of 3-acetoxyazetidin-2-ones and 3-hydroxyazetidin-2-ones with antifungal and antibacterial activity

…, MJ Meegan, RM Prendergast, T Al Nakib

Index: Walsh; Meegan; Prendergast; Al Nakib European Journal of Medicinal Chemistry, 1996 , vol. 31, # 12 p. 989 - 1000

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Citation Number: 108

Abstract

The synthesis of a series of 3-acetoxyazetidin-2-ones 3a–n and 3-hydroxyazetidin-2-ones 6a–j is reported together with the antibacterial and antifungal evaluation of these compounds. An additional series of 3-acetoxyazetidin-2-ones 11a–h which possess a free carboxylic acid group on the N-1 aryl ring were obtained by treatment of suitably substituted Schiff bases 10a–h with acetoxyacetyl chloride. The novel bicyclic structures 7-acetoxy-6- ...