Scavenging of fluorinated N, N'-dialkylureas by hydrogen binding: a novel separation method for fluorous synthesis

…, JM Aizpurua, I Loinaz, MJ Fernandez-Berridi…

Index: Palomo, Claudio; Aizpurua, Jesus M.; Loinaz, Iraida; Fernandez-Berridi, Maria Jose; Irusta, Lourdes Organic Letters, 2001 , vol. 3, # 15 p. 2361 - 2364

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Citation Number: 49

Abstract

A dramatic solubility increase in fluorous solvents is observed for N, N'-di (polyfluoroalkyl) ureas when hydrogen binding complexes are formed with commercially available perfluoroalkanoic acid scavengers. As a case example, analytically pure peptides and esters are obtained using this novel separation method.