Structural aspects of ryanodine action and selectivity

AL Waterhouse, IN Pessah, AO Francini…

Index: Waterhouse, Andrew L.; Pessah, Isaac N.; Francini, Alexander O.; Casida, John E. Journal of Medicinal Chemistry, 1987 , vol. 30, # 4 p. 710 - 716

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Citation Number: 75

Abstract

The topography and toxicological relevance of the Ca2+-ryanodine receptor complex are evaluated with ryanodine and two natural analogues (9, 2l-didehydro and the new 18- hydroxy)) 13 ryanoid derivatives (prepared from ryanodine and didehydroryanodine by functionalizing the available pyrrole, olefin, and hydroxyl substituents), and four degradation products. The potency of ryanoids at the skeletal muscle sarcoplasmic reticulum specific ...