Tetrahedron Letters

Solvent-free synthesis of monoacylaminals from the reaction of amides and aminals as precursors in carbinolamide synthesis

MF Sansone, T Koyanagi, DE Przybyla, RW Nagorski

Index: Sansone, Matthew F.; Koyanagi, Takaoki; Przybyla, David E.; Nagorski, Richard W. Tetrahedron Letters, 2010 , vol. 51, # 46 p. 6031 - 6033

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Citation Number: 6

Abstract

A solvent-free method of generating monoacylaminals by heating the amide and aminal starting materials in the presence of one another has been developed. Yields were generally between 45% and 65% with the monoacylaminal being isolated, needing no further purification after drying under high vacuum.