morpholine

Modify Date: 2026-06-30 19:13:21

morpholine structure	Common Name	morpholine
	CAS Number	110-91-8	Molecular Weight	87.120
	Density	0.9±0.1 g/cm3	Boiling Point	128.9±0.0 °C at 760 mmHg
	Molecular Formula	C₄H₉NO	Melting Point	-5 °C
	MSDS	Chinese USA	Flash Point	35.6±0.0 °C
	Symbol	GHS02, GHS05, GHS06	Signal Word	Danger

Summary: Morpholine (CAS 110-91-8), molecular formula C4H9NO, molecular weight 87.120. Colorless oily liquid with ammonia odor, melting point -5 °C, boiling point 128.9±0.0 °C, density 0.9±0.1 g/cm3. Mainly used in rubber promoting agents, fungicides, pharmaceuticals, pesticides, synthetic fibers, etc. For research-use only, not for medical or clinical usage.

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	morpholine
Synonym	More Synonyms

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	0.9±0.1 g/cm3
Boiling Point	128.9±0.0 °C at 760 mmHg
Melting Point	-5 °C
Molecular Formula	C₄H₉NO
Molecular Weight	87.120
Flash Point	35.6±0.0 °C
Exact Mass	87.068413
PSA	21.26000
LogP	-1.08
Vapour density	3 (vs air)
Vapour Pressure	10.4±0.2 mmHg at 25°C
Index of Refraction	1.415
InChIKey	YNAVUWVOSKDBBP-UHFFFAOYSA-N
SMILES	C1COCCN1
Storage condition	Store at R.T.
Stability	Stable. Flammable. Incompatible with strong oxidizing agents, strong acids, acid chlorides, acid anhydrides. Hygroscopic.
Water Solubility	MISCIBLE
Freezing Point	-4.9℃

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

morpholine MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QD6475000

CHEMICAL NAME :: Morpholine

CAS REGISTRY NUMBER :: 110-91-8

BEILSTEIN REFERENCE NO. :: 0102549

LAST UPDATED :: 199712

DATA ITEMS CITED :: 57

MOLECULAR FORMULA :: C4-H9-N-O

MOLECULAR WEIGHT :: 87.14

WISWESSER LINE NOTATION :: T6M DOTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8000 ppm/8H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 525 mg/kg

TOXIC EFFECTS :: Behavioral - sleep Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1320 mg/m3/2H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 413 mg/kg

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 458 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 500 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Gastrointestinal - ulceration or bleeding from stomach Gastrointestinal - ulceration or bleeding from small intestine

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 12000 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 24 gm/kg/30D-I

TOXIC EFFECTS :: Gastrointestinal - necrotic changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 70 mg/m3/4H/17W-I

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section Blood - changes in leukocyte (WBC) count

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 ppm/6H/13W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 9 gm/kg/10D-I

TOXIC EFFECTS :: Liver - fatty liver degeneration Skin and Appendages - primary irritation (after topical exposure) Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 13500 mg/kg/30D-I

TOXIC EFFECTS :: Gastrointestinal - necrotic changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 70 mg/m3/4H/17W-I

TOXIC EFFECTS :: Liver - liver function tests impaired Kidney, Ureter, Bladder - other changes in urine composition

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 27 gm/kg/30D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in both tubules and glomeruli Skin and Appendages - primary irritation (after topical exposure) Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2560 mg/kg/Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - bronchiogenic carcinoma Liver - tumors

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0779-0294 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 71 mg/m3 (20 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 47,199,1989 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 47,199,1989 TOXICOLOGY REVIEW JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 8,707,1989 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 20 ppm (70 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,175,1971 OSHA PEL (Gen Indu):8H TWA 20 ppm (70 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 20 ppm (70 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 20 ppm (70 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 20 ppm (70 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 20 ppm (70 mg/m3);STEL 30 ppm (105 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 20 ppm (71 mg/m3);STEL 30 ppm (107 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 20 ppm (70 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 20 ppm (70 mg/m3);STEL 30 ppm (105 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 20 ppm (70 mg/m3);STEL 30 ppm (105 mg/m3) JAN 1993 OEL-GERMANY:TWA 20 ppm (70 mg/m3);Skin JAN 1993 OEL-HUNGARY:STEL 10 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 20 ppm (70 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 20 ppm (70 mg/m3);Skin JAN 1993 OEL-RUSSIA:TWA 0.5 mg/m3;STEL 1.5 mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 20 ppm (70 mg/m3);STEL 30 ppm (110 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 20 ppm (70 mg/m3);STEL 40 ppm;Skin JAN 1993 OEL-UNITED KINGDOM:TWA 20 ppm (70 mg/m3);STEL 30 ppm;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO MORPHOLINE-air:10H TWA 20 ppm (Sk);STEL 30 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 48910 No. of Facilities: 20431 (estimated) No. of Industries: 132 No. of Occupations: 82 No. of Employees: 122734 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 48910 No. of Facilities: 13767 (estimated) No. of Industries: 133 No. of Occupations: 105 No. of Employees: 214367 (estimated) No. of Female Employees: 65146 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS02, GHS05, GHS06
Signal Word	Danger
Hazard Statements	H226-H302-H311 + H331-H314
Precautionary Statements	P210-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P370 + P378
Personal Protective Equipment	Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	C:Corrosive
Risk Phrases	R10;R20/21/22;R34
Safety Phrases	S23-S36-S45
RIDADR	UN 2054 8/PG 1
WGK Germany	3
RTECS	QD6475000
Packaging Group	I
Hazard Class	8
HS Code	2934999090

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 9
CAS#:929-06-6 Diglycolamine CAS#:111-46-6 Diethylene glycol CAS#:25070-77-3 prop-2-enyl mor... CAS#:59-89-2 4-Nitrosomorpholine
CAS#:7529-22-8 N-methylmorphol... CAS#:114406-39-2 prop-2-ynyl mor... CAS#:2752-17-2 2,2-Oxybis(ethy... CAS#:110-89-4 Piperidine
CAS#:66155-48-4 3,9-dioxa-6-azo...
DownStream 10
CAS#:105316-06-1 4-MORPHOLINO-3-... CAS#:106087-44-9 9-methyl-1,7-bi... CAS#:1094323-33-7 4-(6-Chloro-3-n... CAS#:61100-30-9 4-(6-MORPHOLINO...
CAS#:106087-39-2 1-ethyl-9-methy... CAS#:108199-09-3 [4-[(7-chloroqu... CAS#:105358-09-6 4-(2-nitropheny... CAS#:105397-92-0 3-morpholin-4-y...
CAS#:1080-85-9 4-Chloro-2-meth... CAS#:55153-46-3 2-oxo-2-phenyle...

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

Synthesis and antitumor activities of some new N1-(flavon-6-yl)amidrazone derivatives.

Arch. Pharm. (Weinheim) 347(6) , 415-22, (2014)

A new series of N1-(flavon-6-yl)amidrazones were synthesized by reacting the hydrazonoyl chloride derived from 6-aminoflavone with the appropriate sec-cyclic amines. The antitumor activities of these ...

Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.

Bioorg. Med. Chem. 15 , 6943-55, (2007)

A set of 116 structurally very diverse compounds, mainly drugs, was characterized by 1630 molecular descriptors. The biological property modelled in this study was the transdermal permeability coeffic...

The c-MET/PI3K signaling is associated with cancer resistance to doxorubicin and photodynamic therapy by elevating BCRP/ABCG2 expression.

Mol. Pharmacol. 87(3) , 465-76, (2015)

Overexpression of BCRP/ABCG2, a xenobiotic efflux transporter, is associated with anticancer drug resistance in tumors. Proto-oncogene c-MET induces cancer cell proliferation, motility, and survival, ...

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

1,4-Oxazinan

EINECS 203-815-1

Morpholine

MORPHOLINE,ACS

1-Oxa-4-azacyclohexane

BASF 238

Drewamine

MORPHOLIN

Tetrahydro-1,4-oxazine

dihydro-1,4-oxazine

perhydro-1,4-oxazine

MFCD00005972

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What are the upstream materials of morpholine?

A: Related upstream materials(CAS) of morpholine: 929-06-6;111-46-6;25070-77-3;59-89-2;7529-22-8;114406-39-2;2752-17-2;110-89-4;66155-48-4.

Q: What is the InChIKey of morpholine?

A: InChIKey of morpholine is YNAVUWVOSKDBBP-UHFFFAOYSA-N.

Q: What is the CAS number of morpholine?

A: CAS number of morpholine is 110-91-8.

Q: What is the molecular formula of morpholine?

A: Molecular formula of morpholine is C4H9NO.

Q: What is the English name of morpholine?

A: The English name of morpholine is morpholine.

Q: What is the boiling point of morpholine?

A: Boiling point of morpholine is 128.9±0.0 °C at 760 mmHg.

Q: What English synonyms does morpholine have?

A: English synonyms of morpholine: 1,4-Oxazinan, EINECS 203-815-1, Morpholine, MORPHOLINE,ACS, 1-Oxa-4-azacyclohexane, BASF 238, Drewamine, MORPHOLIN, Tetrahydro-1,4-oxazine, dihydro-1,4-oxazine, perhydro-1,4-oxazine, MFCD00005972.

Q: What is the SMILES notation of morpholine?

A: SMILES notation of morpholine is C1COCCN1.

Q: What is the safety information for morpholine?

A: Safety information for morpholine: S23-S36-S45.

Q: What is the LogP of morpholine?

A: LogP of morpholine is -1.08.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

Henan Tianfu Chemical Co., Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: morpholine
Price: Check
Purity: 99.5%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Morpholine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: morpholine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.