Anticonvulsant and sedative-hypnotic activity of some novel 3-[5-(4-substituted) phenyl-1, 3, 4-oxadiazole-2yl]-2-styrylquinazoline-4 (3H)-ones

SK Kashaw, V Gupta, V Kashaw, P Mishra…

Index: Kashaw, Sushil K.; Gupta, Vivek; Kashaw, Varsha; Mishra; Stables; Jain Medicinal Chemistry Research, 2010 , vol. 19, # 3 p. 250 - 261

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Citation Number: 30

Abstract

Abstract A few novel 3-[5-(4-substituted) phenyl-1, 3, 4-oxadiazole-2-yl]-2-styryl quinazoline- 4 (3 H)-ones were synthesized and evaluated for anticonvulsant, neurotoxicity, sedative- hypnotic, and phenobarbitone-induced hypnosis potentiation test. After ip injection to mice at doses of 30, 100, and 300 mg/kg body weight derivatives were examined in the maximal electroshock-induced seizures (MES) and subcutaneous pentylenetetrazole (scPTZ)- ...