Semicarbazide hydrochloride

Modify Date: 2026-07-19 16:42:54

Semicarbazide hydrochloride structure	Common Name	Semicarbazide hydrochloride
	CAS Number	563-41-7	Molecular Weight	111.531
	Density	1.286g/cm3	Boiling Point	235.3ºC at 760 mmHg
	Molecular Formula	CH₆ClN₃O	Melting Point	175-177 °C (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	66.5ºC
	Symbol	GHS06	Signal Word	Danger

Use of Semicarbazide hydrochloride

Semicarbazide hydrochloride, a derivative of urea, possesses antiviral, antiinfective and antineoplastic through binding to copper or iron in cells[1].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	Semicarbazide hydrochloride
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Semicarbazide hydrochloride, a derivative of urea, possesses antiviral, antiinfective and antineoplastic through binding to copper or iron in cells[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. Adam Becalski, et al. Semicarbazide Formation in Azodicarbonamide-Treated Flour: A Model Study. J Agric Food Chem. 2004 Sep 8;52(18):5730-4.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.286g/cm3
Boiling Point	235.3ºC at 760 mmHg
Melting Point	175-177 °C (dec.)(lit.)
Molecular Formula	CH₆ClN₃O
Molecular Weight	111.531
Flash Point	66.5ºC
Exact Mass	111.019943
PSA	81.14000
LogP	1.12190
Vapour Pressure	0.0407mmHg at 25°C
InChIKey	XHQYBDSXTDXSHY-UHFFFAOYSA-N
SMILES	Cl.NNC(N)=O
Storage condition	-20°C Freezer, Under Inert Atmosphere
Stability	Stable. Incompatible with strong oxidizing agents, strong bases.
Water Solubility	100 g/L (15 ºC)

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

Semicarbazide hydrochloride MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VT3500000

CHEMICAL NAME :: Semicarbazide, monohydrochloride

CAS REGISTRY NUMBER :: 563-41-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C-H5-N3-O.Cl-H

MOLECULAR WEIGHT :: 111.55

WISWESSER LINE NOTATION :: ZVMZ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 225 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 145 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 167 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement Behavioral - ataxia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6 gm/kg/30D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2400 mg/kg/30D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 67 gm/kg/76W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Vascular - tumors Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 74 mg/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 550 mg/kg

SEX/DURATION :: female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 100 mg/kg

SEX/DURATION :: female 7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TEST SYSTEM :: Insect - grasshopper

DOSE/DURATION :: 100 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 40,237,1976 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 12,209,1976 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 12,209,1976 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7190 No. of Facilities: 41 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 2815 (estimated) No. of Female Employees: 1055 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	P301 + P310
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T:Toxic
Risk Phrases	R25;R36/38;R40
Safety Phrases	S24/25-S22-S45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	VT3500000
Packaging Group	III
Hazard Class	6.1
HS Code	2928000090

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 10
CAS#:590-28-3 Potassium cyanate CAS#:10034-93-2 Hydrazine sulfate CAS#:745076-15-7 2-(1-(4-((4-ace... CAS#:745076-14-6 2,2'-((thiobis(...
CAS#:745076-16-8 2-(1-(4-((4-(1-... CAS#:28787-22-6 1-amino-3-(diam... CAS#:1574-10-3 Hydrazinecarbox... CAS#:38132-39-7 methyl benzoylf...
CAS#:7647-01-0 Hydrochloric acid CAS#:39130-96-6 thiazolidine-2,...
DownStream 10
CAS#:106324-36-1 (anthracen-9-yl... CAS#:105224-04-2 Ethanone, 1-(3-... CAS#:106659-98-7 1H-Pyrazole-1-c... CAS#:33050-32-7 6-CHLORO-[1,2,4...
CAS#:59-87-0 Nitrofurazone CAS#:14923-66-1 Propanoic acid,... CAS#:14534-93-1 2-acetylpyridin... CAS#:14066-73-0 Hydrazinecarbox...
CAS#:4512-00-9 1,2,4-Triazin-3... CAS#:434-13-9 Lithocholic acid

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2928000090
Summary	2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

A selective biomarker for confirming nitrofurazone residues in crab and shrimp using ultra-performance liquid chromatography-tandem mass spectrometry.

Anal. Bioanal. Chem 407 , 8971-7, (2015)

Reliably detecting nitrofurazone (NFZ) residues in farmed crab and shrimp was previously hindered by lack of appropriately specific analytical methodology. Parent NFZ rapidly breaks down in meat, and ...

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Rapid detection of economic adulterants in fresh milk by liquid chromatography-tandem mass spectrometry.

J. Chromatogr. A. 1288 , 10-20, (2013)

A method to aid in the detection of the economically driven adulteration of fresh milk with a range of small, nitrogen containing compounds, including melamine, ammeline, ammelide, cyanuric acid, alla...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

Name: Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1266185

Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA

Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id: SIAE_INH_FP_1536_1X%INH PRUN

Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482

Total 336, Current Page 1 of 34

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

amidoureahydrochloride

EINECS 209-247-0

ammourea hydrochloride

semicarbazide-hydrochloride

SEMICARBAZIDE HCL

AMINOUREA HYDROCHLORIDE

MFCD00013009

Semicarbazide hydroc

SEM

semicarbazid

CARBAMYLHYDRAZINEHCL

Semicarbaside

Hydrazinecarboxamide hydrochloride

Semicarbazide-13CHCl

semicarbazidechloride

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the molecular formula of Semicarbazide hydrochloride?

A: Molecular formula of Semicarbazide hydrochloride is CH6ClN3O.

Q: What is the safety information for Semicarbazide hydrochloride?

A: Safety information for Semicarbazide hydrochloride: S24/25-S22-S45.

Q: What are the downstream products of Semicarbazide hydrochloride?

A: Related downstream products(CAS) of Semicarbazide hydrochloride: 106324-36-1;105224-04-2;106659-98-7;33050-32-7;59-87-0;14923-66-1;14534-93-1;14066-73-0;4512-00-9;434-13-9.

Q: What is the LogP of Semicarbazide hydrochloride?

A: LogP of Semicarbazide hydrochloride is 1.12190.

Q: What is the InChIKey of Semicarbazide hydrochloride?

A: InChIKey of Semicarbazide hydrochloride is XHQYBDSXTDXSHY-UHFFFAOYSA-N.

Q: What is the molecular weight of Semicarbazide hydrochloride?

A: Molecular weight of Semicarbazide hydrochloride is 111.531.

Q: What is the melting point of Semicarbazide hydrochloride?

A: Melting point of Semicarbazide hydrochloride is 175-177 °C (dec.)(lit.).

Q: What is the polar surface area (PSA) of Semicarbazide hydrochloride?

A: Polar surface area (PSA) of Semicarbazide hydrochloride is 81.14000.

Q: What are the storage conditions for Semicarbazide hydrochloride?

A: Storage conditions for Semicarbazide hydrochloride: -20°C Freezer, Under Inert Atmosphere.

Q: What is the English name of Semicarbazide hydrochloride?

A: The English name of Semicarbazide hydrochloride is Semicarbazide hydrochloride.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Semicarbazide hydrochloride
Price: Check
Purity: 99.5%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Semicarbazide hydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Price: ￥550/100 mg

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Semicarbazide hydrochloride

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