Rhodium versus ruthenium: contrasting behaviour in the asymmetric transfer hydrogenation of α-substituted acetophenones

…, JA Kenny, I Houson, L Campbell, T Walsgrove…

Index: Cross, David J.; Kenny, Jennifer A.; Houson, Ian; Campbell, Lynne; Walsgrove, Tim; Wills, Martin Tetrahedron Asymmetry, 2001 , vol. 12, # 12 p. 1801 - 1806

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Citation Number: 67

Abstract

The asymmetric transfer hydrogenation of ketones, which offers a convenient route to enantiomerically pure secondary alcohols, has been the subject of a number of investigations in our group. 1., , , , , , , and The use of formic acid as the hydrogen donor offers the possibility of performing the reaction under essentially irreversible conditions. In order to utilise formic acid as the hydrogen donor, monotosylated diamines offer the best option for use as ligands. 2 In particular ...