Quaternary salts of 2-[(hydroxyimino) methyl] imidazole. 3. Synthesis and evaluation of (alkenyloxy)-,(alkynyloxy)-, and (aralykyloxy) methyl quaternarized 2-[( …

…, I Koplovitz, WE Sultan, HA Musallam

Index: Bedford; Harris III; Howd; Goff; Koolpe; Petesch; Koplovitz; Sultan; Musallam Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 504 - 516

Full Text: HTML

Citation Number: 29

Abstract

Quaternary Salts of 2-[(Hydroxyimino) methyl] imadazole. 3 representing the 2- [(hydroxyimino) methyl]-3-methyl-imidazolium ring system were synthesized. As before, all compounds were evaluated with respect to (hydroxyimino) methyl acid dissociation constant, nucleophilicity, and lipophilicity. The alkynyloxy-substituted imidazolium derivatives were also evaluated for reversible inhibition of AChE and kinetics of ...

 Related Synthetic Route

~64%

~%

~70%

~46%

~%

~74%

~%

~48%

~%

~%

~65%

~89%

~60%

~%

~53%

~%

~82%

~%

~95%

~%

~68%

~%

~%

~73%

~%

~53%

~%

~55%

~%

~%

~58%

~%

~92%

~%

~43%

~%

~%

~40%

~81%

~42%

~51%

~%

~%

~65%

~%

~%

~39%