The Journal of Organic Chemistry

Pyrrolo [3, 2-d] pyrimidine Folate Analogs:" Inverted" Analogs of the Cytotoxic Agent LY231514

EC Taylor, WB Young

Index: Taylor, Edward C.; Young, Wendy B. Journal of Organic Chemistry, 1995 , vol. 60, # 24 p. 7947 - 7952

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Citation Number: 34

Abstract

In the course of our program directed toward the design and synthesis of inhibitors of folate- dependent biochemical processes as antitumor agents, l we recently synthesized N-{4-[2-(2- amino-4 (3H)-oxo-7H-pyrrolo [2, 3-dlpyri-midin-5-yl) ethyl] benzoyl}-~-glutamic acid (1, LY231514I2 as an analogue of DDATHF [(6RS)-211, 3 in which C-5 of the latter was deleted and the B ring aromatized. This compound, which was found to be a potent inhibitor of ...