e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Nucleic acid derived allenols. Unusual analogs of nucleosides with antiretroviral activity

S Phadtare, J Zemlicka

Index: Phadtare, Shashikant; Zemlicka, Jiri Journal of the American Chemical Society, 1989 , vol. 111, # 15 p. 5925 - 5931

Full Text: HTML

Citation Number: 72

Abstract

Conclusions The well-known rapid hydrolysis of amic acids in acidic solution involves a transacylation reaction, which potentially competes initially with a dehydration reaction leading to formation of an imide. The pseudoequilibrium between amic acid and imide is drained by the conversion of the amic acid to the amine and dicarboxylic acid via the anhydride. This complication in the behavior of amic acids indicates that changes in the ...

2-Amino-6-chloropurine Structure

2-Amino-6-chlor...

1,4-Dichlorbut-2-in Structure

1,4-Dichlorbut-2-in

~48%

6-chloro-9-(4-chlorobut-2-ynyl)purin-2-amine Structure

6-chloro-9-(4-c...

9-(4-chlorobut-2-ynyl)purin-6-amine Structure

9-(4-chlorobut-...

~65%

4-(6-aminopurin-9-yl)but-2-yn-1-ol Structure

4-(6-aminopurin...

4-(6-aminopurin-9-yl)but-2-yn-1-ol Structure

4-(6-aminopurin...

~51%

adenallene Structure

4-(6-aminopurin-9-yl)but-2-yn-1-ol Structure

4-(6-aminopurin...

~27%

adenallene Structure

N/A Structure

9-(4-chlorobut-2-ynyl)purin-6-amine Structure

9-(4-chlorobut-...

~%

adenallene Structure

6H-Purin-6-imine, 1,7-dihydro- (9CI) Structure

6H-Purin-6-imin...

~%

adenallene Structure

N/A Structure

~92%

SQ22536 Structure

6H-Purin-6-imine, 1,7-dihydro- (9CI) Structure

6H-Purin-6-imin...

1,4-Dichlorbut-2-in Structure

1,4-Dichlorbut-2-in

~53%

9-(4-chlorobut-2-ynyl)purin-6-amine Structure

9-(4-chlorobut-...

6-chloro-9-(4-chlorobut-2-ynyl)purin-2-amine Structure

6-chloro-9-(4-c...

~59%

2-amino-9-(4-hydroxybut-2-ynyl)-3H-purin-6-one Structure

2-amino-9-(4-hy...

2-Amino-6-chloropurine Structure

2-Amino-6-chlor...

~%

2-amino-9-(4-hydroxybut-2-ynyl)-3H-purin-6-one Structure

2-amino-9-(4-hy...

N1-(4-Chloro-2-butyn-1-yl)cytosine Structure

N1-(4-Chloro-2-...

~61%

4-amino-1-(4-hydroxybut-2-ynyl)pyrimidin-2-one Structure

4-amino-1-(4-hy...

4-amino-1-(4-hydroxybut-2-ynyl)pyrimidin-2-one Structure

4-amino-1-(4-hy...

~38%

cytallene Structure

N1-(4-Chloro-2-butyn-1-yl)cytosine Structure

N1-(4-Chloro-2-...

~%

cytallene Structure

adenallene Structure

~93%

9-(4-chlorobuta-1,2-dienyl)purin-6-amine Structure

9-(4-chlorobuta...

9-(4-chlorobut-2-ynyl)purin-6-amine Structure

9-(4-chlorobut-...

~%

9-(4-chlorobuta-1,2-dienyl)purin-6-amine Structure

9-(4-chlorobuta...

4-(6-aminopurin-9-yl)but-2-yn-1-ol Structure

4-(6-aminopurin...

~%

9-(4-chlorobuta-1,2-dienyl)purin-6-amine Structure

9-(4-chlorobuta...

6H-Purin-6-imine, 1,7-dihydro- (9CI) Structure

6H-Purin-6-imin...

~%

9-(4-chlorobuta-1,2-dienyl)purin-6-amine Structure

9-(4-chlorobuta...

N/A Structure

~%

2-amino-9-(4-hydroxybuta-1,2-dienyl)-3H-purin-6-one Structure

2-amino-9-(4-hy...

6-chloro-9-(4-chlorobut-2-ynyl)purin-2-amine Structure

6-chloro-9-(4-c...

~%

2-amino-9-(4-hydroxybuta-1,2-dienyl)-3H-purin-6-one Structure

2-amino-9-(4-hy...

2-amino-9-(4-hydroxybut-2-ynyl)-3H-purin-6-one Structure

2-amino-9-(4-hy...

~%

2-amino-9-(4-hydroxybuta-1,2-dienyl)-3H-purin-6-one Structure

2-amino-9-(4-hy...

N2-[(Dimethylamino)methylene]-N9-(4-hydroxy-2-butyn-1-yl)guanine Structure

N2-[(Dimethylam...

~%

2-amino-9-(4-hydroxybuta-1,2-dienyl)-3H-purin-6-one Structure

2-amino-9-(4-hy...

2-Amino-6-chloropurine Structure

2-Amino-6-chlor...

~%

2-amino-9-(4-hydroxybuta-1,2-dienyl)-3H-purin-6-one Structure

2-amino-9-(4-hy...