Electrophysiologic and antiarrhythmic activities of 4-amino-N-[2-(diethylamino) ethyl]-3, 5-dimethylbenzamide, a sterically hindered procainamide analog

…, CJ Parli, JK Smallwood, MI Steinberg

Index: Robertson; Beedle; Wilson; Parli; Smallwood; Steinberg Journal of Medicinal Chemistry, 1988 , vol. 31, # 7 p. 1290 - 1295

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Citation Number: 2

Abstract

Procainamide is a widely used antiarrhythmic that is fraught with therapeutic limitations such as a short half-life, production of autoimmune antibodies and a lupus-like syndrome, and complex pharmacokinetics. We synthesized the congeiiers of procainamide possessing one or two methyl substituents ortho to the 4-amino moiety (compounds 4 and 5, respectively), in order to sterically encumber the 4-amino substituent and prevent or diminish the rate of ...