Synthesis, structure, and antiparasitic activity of sulfamoyl derivatives of ribavirin

GD Kini, EM Henry, RK Robins, SB Larson…

Index: Kini, Ganesh D.; Henry, Elizabeth M.; Robins, Roland K.; Larson, Steven B.; Marr, J. Joseph; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 44 - 48

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Citation Number: 22

Abstract

The triazole nucleoside derivatives 1-(5'-O-sulfamoyl-~-~-ribofuranosyl)[1, 2, 4] triazole-3- carboxamide (2), 1-(5f-0-sulfamoyl-~-~-ribofuranosyl)[l, 2, 4] triazole-3-thiocarboxamide (3), and 1-(5'-0-sulfamoyl-~-~-ribofuranosyl)-[1, 2, 4] triazole-3-carbonitrile (4) were synthesized. Suitably protected triazole nucleosides were converted to their corresponding 5'-sulfamoyl derivatives, which on subsequent deproktion gave the desired compounds in good yields. ...