Synthesis of fluorine analogues of protoporphyrin

…, T Shinada, S Kinoshita, N Arimura, T Nagai…

Index: Ando, Akira; Shinada, Tetsuro; Kinoshita, Shinji; Arimura, Noriko; Nagai, Takabumi; et al. Journal of Fluorine Chemistry, 1989 , vol. 42, p. 293 - 298

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Citation Number: 4

Abstract

Abstract With intention of obtaining a porphyrin derivative useful for diagnosis and therapy of cancer, fluorine analogues of protoporphyrin, in which the vinyl group (s) were replaced by difluorovinyl group (s), were synthesized by the reaction of the formylporphyrins with sodium chlorodifluoroacetate in the presence of triphenylphosphine.