Synthesis and antidiabetic activity of morpholinothiazolyl-2, 4-thiazolidindione derivatives

M Ezer, LT Yıldırım, O Bayro, EJ Verspohl…

Index: Ezer, Melis; Yildirim, Leyla Tatar; Bayro, Ornela; Verspohl, Eugen J.; Dundar, Oya Bozdag Journal of Enzyme Inhibition and Medicinal Chemistry, 2012 , vol. 27, # 3 p. 419 - 427

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Citation Number: 2

Abstract

We report the synthesis and the in vitro insulin releasing and glucose uptake activity of the morpholino thiazolyl-2, 4-thiazolidinediones (1-15). Compounds 5, 11–15 (at lower concentration; 0.001 mg/ml) were able to increase insulin release in the presence of 5.6 mmol/l glucose. The compounds, except derivative 3 show an increase of glucose uptake. Various compounds are interesting potential antidiabetic leads showing pancreatic and ...