A new and efficient method for the synthesis of α, α-dihaloketones by oxyhalogenation of alkynes using oxone®–KX (X= Cl, Br, or I)

S Madabhushi, R Jillella, KKR Mallu, KR Godala…

Index: Madabhushi, Sridhar; Jillella, Raveendra; Mallu, Kishore Kumar Reddy; Godala, Kondal Reddy; Vangipuram, Venkata Sairam Tetrahedron Letters, 2013 , vol. 54, # 30 p. 3993 - 3996

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Citation Number: 12

Abstract

Potassium peroxymonosulfate or oxone®, which is commercially available in the form of a triple salt 2KHSO 5 ·KHSO 4 ·K 2 SO 4 , is an important and widely used oxidant in organic synthesis for a variety of transformations such as oxidation of alkenes to epoxides, 9 thioethers to sulfones, 10 aldehydes to carboxylic acids, 11 and tertiary amines to amine oxides. 12 In addition, oxone® is also known to promote bromination, 13 hydroxybromination, 14 and ...