Synthesis of dibromo ketones by the reaction of the environmentally benign H2O2-HBr system with oximes

…, VA Vil, ZY Pastukhova, SA Fastov, GI Nikishin

Index: Terentev, Alexander O.; Krylov, Igor B.; Vil, Vera A.; Pastukhova, Zhanna Yu.; Fastov, Sergey A.; Nikishin, Gennady I. Central European Journal of Chemistry, 2012 , vol. 10, # 2 p. 360 - 367

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Citation Number: 2

Abstract

Abstract It was found that oximes undergo deoximation in the presence of the H 2 O 2aq-HBr aq system to form ketones and bromo ketones. This reaction provided the basis for the synthesis of dibromo ketones in yields varying from 40% to 94%. This method is environmentally friendly, sustainable, and easy to perform. The results of this investigation extend the potential of the use of oximes for the protection of carbonyl group, thus offering ...