Biohydroxylations of Cbz-protected alkyl substituted piperidines by Beauveria bassiana ATCC 7159

SJ Aitken, CSY Chow, NJ Turner…

Index: Aitken, Suzanne J.; Grogan, Gideon; Chow, Cathy S.-Y.; Turner, Nicholas J.; Flitsch, Sabine L. Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 20 p. 3365 - 3370

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Citation Number: 20

Abstract

N-Benzyloxycarbonyl (Cbz) protected piperidines are hydroxylated with greater regioselectivity than the corresponding N-benzoyl analogues when incubated with the fungus Beauveria bassiana ATCC 7159. Cbz-protected piperidines 1–3, 5–7, have been biotransformed by growing cell suspensions of this fungus to yield predominantly 4- hydroxylated products in up to 48% yield. The regiospecificity of hydroxylation was only ...