Tetrahedron letters

MPM (4-methoxybenzyl) protection of hydroxy functions under mild acidic conditions

N Nakajima, K Horita, R Abe, O Yonemitsu

Index: Nakajima, Noriyuki; Horita, Kiyoshi; Abe, Reiko; Yonemitsu, Osamu Tetrahedron Letters, 1988 , vol. 29, # 33 p. 4139 - 4142

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Citation Number: 250

Abstract

Abstract In order to establish a mild protection method for hydroxy functions with a MPM (4- methoxybenzyl) group, various types of hydroxy compounds were treated with MPM trichloroacetimidate in the presence of an acid catalyst. A catalytic amount (0.3 mol%) of trifluoromethanesulfonic acid was most effective and the reaction was completed within 40 min at room temperature even for highly sterically hindered hydroxy groups.