e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Tetrahedron letters

Addition of 1-methoxy-1-buten-3-yne to lactones: synthesis of substituted spiroketals

MT Crimmins, DM Bankaitis

Index: Crimmins, Michael T.; Bankaitis, Danute M. Tetrahedron Letters, 1983 , vol. 24, # 42 p. 4551 - 4554

Full Text: HTML

Citation Number: 16

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A method for the preparation of a variety of substituted spiroketals from lactones and 1-methoxy-1-buten-3-yne has been developed. ... 1-Methoxy-1-buten-3-yne is available from Aldrich Chemical Company as a 50% solution in methanol··water. Distillation (bp. ...

1-hydroxy-7,9,9-trimethoxynon-6-en-5-one Structure

1-hydroxy-7,9,9...

~%

1,7-dioxaspiro[5.5]undec-2-en-4-one Structure

1,7-dioxaspiro[...

2-methoxy-1,7-dioxaspiro[5.5]undecan-4-one Structure

2-methoxy-1,7-d...

delta-Valerolactone Structure

delta-Valerolactone

~%

1,7-dioxaspiro[5.5]undec-2-en-4-one Structure

1,7-dioxaspiro[...

1-hydroxy-7,9,9-trimethoxynon-6-en-5-one Structure

1-hydroxy-7,9,9...

~%

1,7-dioxaspiro[5.5]undec-2-en-4-one Structure

1,7-dioxaspiro[...

2-methoxy-1,7-dioxaspiro[5.5]undecan-4-one Structure

2-methoxy-1,7-d...

1-Buten-3-yne,1-methoxy- Structure

1-Buten-3-yne,1...

γ-Valerolactone Structure

γ-Valerolactone

~95%

8-hydroxy-1-methoxynon-1-en-3-yn-5-one Structure

8-hydroxy-1-met...

1-Buten-3-yne,1-methoxy- Structure

1-Buten-3-yne,1...

Alpha-Methyl-Gamma-Butyrolactone Structure

Alpha-Methyl-Ga...

~87%

1-hydroxy-8-methoxy-3-methyloct-7-en-5-yn-4-one Structure

1-hydroxy-8-met...

8-hydroxy-1-methoxynon-1-en-3-yn-5-one Structure

8-hydroxy-1-met...

~61%

2-methyl-1,10-dioxaspiro[4.5]dec-8-en-7-one Structure

2-methyl-1,10-d...

γ-Valerolactone Structure

γ-Valerolactone

~%

2-methyl-1,10-dioxaspiro[4.5]dec-8-en-7-one Structure

2-methyl-1,10-d...

1-hydroxy-8-methoxy-3-methyloct-7-en-5-yn-4-one Structure

1-hydroxy-8-met...

~50%

4-methyl-1,6-dioxaspiro[4.5]dec-7-en-9-one Structure

4-methyl-1,6-di...

Alpha-Methyl-Gamma-Butyrolactone Structure

Alpha-Methyl-Ga...

~%

4-methyl-1,6-dioxaspiro[4.5]dec-7-en-9-one Structure

4-methyl-1,6-di...

Synthesis of spiroketals: a general approach

[Crimmins, Michael T.; O'Mahony, Rosemary Journal of Organic Chemistry, 1990 , vol. 55, # 23 p. 5894 - 5900]

Synthesis of spiroketals: a general approach

[Crimmins, Michael T.; O'Mahony, Rosemary Journal of Organic Chemistry, 1990 , vol. 55, # 23 p. 5894 - 5900]

Synthesis of spiroketals: a general approach

[Crimmins, Michael T.; O'Mahony, Rosemary Journal of Organic Chemistry, 1990 , vol. 55, # 23 p. 5894 - 5900]

Synthesis of spiroketals: a general approach

[Crimmins, Michael T.; O'Mahony, Rosemary Journal of Organic Chemistry, 1990 , vol. 55, # 23 p. 5894 - 5900]

Synthesis of spiroketals: a general approach

[Crimmins, Michael T.; O'Mahony, Rosemary Journal of Organic Chemistry, 1990 , vol. 55, # 23 p. 5894 - 5900]