Benzylic oxidation catalyzed by dirhodium (II, III) caprolactamate

AJ Catino, JM Nichols, H Choi, S Gottipamula…

Index: Catino, Arthur J.; Nichols, Jason M.; Choi, Hojae; Gottipamula, Sidhartha; Doyle, Michael P. Organic Letters, 2005 , vol. 7, # 23 p. 5167 - 5170

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Citation Number: 146

Abstract

Dirhodium caprolactamate [Rh2 (cap) 4] is an effective catalyst for benzylic oxidation with tert-butyl hydroperoxide (TBHP) under mild conditions. Sodium bicarbonate is the optimal base additive for substrate conversion. Benzylic carbonyl compounds are readily obtained, and a formal synthesis of palmarumycin CP2 using this methodology is described.