Electrophilic aromatic substituted luciferins as bioluminescent probes for glutathione S-transferase assays

W Zhou, JW Shultz, N Murphy, EM Hawkins…

Index: Zhou, Wenhui; Shultz, John W.; Murphy, Nancy; Hawkins, Erika M.; Bernad, Laurent; Good, Troy; Moothart, Leonard; Frackman, Susan; Klaubert, Dieter H.; Bulleit, Robert F.; Wood, Keith V. Chemical Communications, 2006 , # 44 p. 4620 - 4622

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Citation Number: 17

Abstract

The glutathione S-transferases (GSTs) represent a major group of detoxification enzymes that catalyze the nucleophilic addition of the tripeptide glutathione (GSH) to many xenobiotics and endogenous electrophiles. 1 The level of expression of GSTs is a crucial factor in determining the susceptibility to cancer chemotherapy. Three classes of GST isozymes, Alpha (A), Mu (M) and Pi (P) are often found over-expressed in drug-resistant tumor or tumor cell lines. 1,2 ...