Synthesis of piperidine and decahydroquinoline derivatives: Their analgetic and psychotropic properties. XVIII. 1-Methyl-4-acetylpiperidin-4-ol and its esters

…, KD Praliev, TA Salita, OT Zhilkibaev…

Index: Korablev, M. V.; Praliev, K. D.; Salita, T. A.; Zhilkibaev, O. T.; Kurbat N. M.; et al. Pharmaceutical Chemistry Journal, 1985 , vol. 19, # 4 p. 252 - 256 Khimiko-Farmatsevticheskii Zhurnal, 1985 , vol. 19, # 4 p. 419 - 422

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Abstract

Substituted piperidin-4-ols and their esters occupy a prominent place among the various synthetically prepared biologically active compounds. In continuation of the search for compounds with neurotropic activity among the piperidine derivatives [4-6] it was interesting to investigate the newly prepared esters (IV-VI) of the known [8] l-methyl-4-acetylpiperidin-4- ol (III), since 1, 2, 5-trimethyl-4-acetyl-4-acyloxypiperidines, which exhibit a local- ...