Investigation of an Efficient Palladium-Catalyzed C (sp)− C (sp) Cross-Coupling Reaction Using Phosphine− Olefin Ligand: Application and Mechanistic Aspects

…, Y Luo, X Luo, L Chao, H Zhang, J Wang…

Index: Shi, Wei; Luo, Yingdong; Luo, Xiancai; Chao, Lei; Zhang, Heng; Wang, Jian; Lei, Aiwen Journal of the American Chemical Society, 2008 , vol. 130, # 44 p. 14713 - 14720

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Citation Number: 103

Abstract

A π-acceptor phosphine− electron-deficient olefin ligand was found effective in promoting Pd-catalyzed C (sp)− C (sp) cross-coupling reactions. The new protocol realized the cross- coupling of a broad scope of terminal alkynes and haloalkynes in good to excellent yields with high selectivities. Electron-rich alkynes, which are normally difficult substrates in Glaser couplings, could be employed as either nucleophiles or electrophiles. Alkynes bearing ...