Tetrahedron letters

Baker's yeast reduction of 5-acetyl-2-isoxazolines synthesis of enantiomerically pure 2, 3-dihydroxy ketones and 1, 2, 4-triols

C Ticozzi, A Zanarotti

Index: Ticozzi, Calimero; Zanarotti, Antonio Tetrahedron Letters, 1988 , vol. 29, # 47 p. 6167 - 6170

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Citation Number: 21

Abstract

Abstract: Saccharomy- cerevisiae reduces enantioselectively racemic 5-acetyl-2- isoxazolines to 5-ethanol-2-isoxazolines in high yields and high enantiomeric excess. Subsequent ring hydrogenolysis of the alcohols thus produced leads to enantiomerically pure 2, 3-dihydroxy ketones and 1, 2, 4-trials.