Tetrahedron Letters

A general rhodium-catalyzed cross-coupling reaction of thiols with aryl iodides

CS Lai, HL Kao, YJ Wang, CF Lee

Index: Lai, Chih-Shin; Kao, Hsin-Lun; Wang, Yan-Jhang; Lee, Chin-Fa Tetrahedron Letters, 2012 , vol. 53, # 33 p. 4365 - 4367

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Citation Number: 25

Abstract

The general procedure for the rhodium-catalyzed cross-coupling of thiols with aryl iodides is described. The catalytic system consists of 5mol% of [RhCl (cod)] 2 and 10mol% of PPh3 as a ligand. A variety of aryl iodides reacted with thiols, giving aryl thioethers in good to excellent yields. It is important to note that the deactivated aryl iodides such as 4-iodoanisole is worked smoothly to provide the corresponding aryl thioethers in excellent yields. ...