Triphenylphosphonium salts of 1, 2, 4-benzothiadiazine 1, 1-dioxides related to diazoxide targeting mitochondrial ATP-sensitive potassium channels

…, B Elmoualij, P Chiap, A Mouithys-Mickalad…

Index: Constant-Urban, Celine; Charif, Mounia; Goffin, Eric; Van Heugen, Jean-Claude; Elmoualij, Benaissa; Chiap, Patrice; Mouithys-Mickalad, Ange; Serteyn, Didier; Lebrun, Philippe; Pirotte, Bernard; De Tullio, Pascal Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 21 p. 5878 - 5881

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Citation Number: 5

Abstract

Abstract The present work aims at identifying new ion channel modulators able to target mitochondrial ATP-sensitive potassium channels (mitoK ATP channels). An innovative approach should consist in fixing a cationic and hydrophobic triphenylphosphonium fragment on the structure of known K ATP channel openers. Such phosphonium salts are expected to cross the biological membranes and to accumulate into mitochondria.