Chloroacetic acid

Modify Date: 2025-08-19 19:17:59

Chloroacetic acid Structure
Chloroacetic acid structure
Common Name Chloroacetic acid
CAS Number 79-11-8 Molecular Weight 94.497
Density 1.4±0.1 g/cm3 Boiling Point 189.0±0.0 °C at 760 mmHg
Molecular Formula C2H3ClO2 Melting Point 61 °C
MSDS Chinese USA Flash Point 71.5±19.8 °C
Symbol GHS02 GHS07
GHS02, GHS07
Signal Word Danger

 Names

Name chloroacetic acid
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 189.0±0.0 °C at 760 mmHg
Melting Point 61 °C
Molecular Formula C2H3ClO2
Molecular Weight 94.497
Flash Point 71.5±19.8 °C
Exact Mass 93.982155
PSA 37.30000
LogP -0.05
Vapour density 3.26 (vs air)
Vapour Pressure 0.3±0.7 mmHg at 25°C
Index of Refraction 1.438
Stability Stable. Deliquescent. Incompatible with strong bases, alkalies, most common metals, strong oxidizing agents.
Water Solubility SOLUBLE

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AF8575000
CHEMICAL NAME :
Acetic acid, chloro-
CAS REGISTRY NUMBER :
79-11-8
BEILSTEIN REFERENCE NO. :
0605438
LAST UPDATED :
199710
DATA ITEMS CITED :
25
MOLECULAR FORMULA :
C2-H3-Cl-O2
MOLECULAR WEIGHT :
94.50
WISWESSER LINE NOTATION :
QV1G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
55 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
180 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
16600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
9750 mg/kg/13W-I
TOXIC EFFECTS :
Cardiac - other changes Blood - changes in erythrocyte (RBC) count Related to Chronic Data - death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
20800 ug/m3/17W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes Blood - pigmented or nucleated red blood cells
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
13 gm/kg/13W-I
TOXIC EFFECTS :
Liver - other changes Liver - changes in liver weight Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3840 mg/kg/16D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Behavioral - ataxia Related to Chronic Data - death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
20800 ug/m3/17W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes Blood - pigmented or nucleated red blood cells
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1300 mg/kg/65W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
160 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** REVIEWS *** TOXICOLOGY REVIEW APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 11,13,1955 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.3 ppm;STEL 1 ppm;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 18070 No. of Facilities: 1196 (estimated) No. of Industries: 9 No. of Occupations: 14 No. of Employees: 4726 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 18070 No. of Facilities: 265 (estimated) No. of Industries: 12 No. of Occupations: 20 No. of Employees: 10912 (estimated) No. of Female Employees: 1723 (estimated)

 Safety Information

Symbol GHS02 GHS07
GHS02, GHS07
Signal Word Danger
Hazard Statements H225-H315
Precautionary Statements P210-P403 + P235
Personal Protective Equipment Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes T:Toxic
Risk Phrases R25;R34;R50
Safety Phrases S23-S37-S45-S61-S36-S26-S16
RIDADR UN 1751 6.1/PG 2
WGK Germany 2
RTECS AF8575000
Packaging Group II
Hazard Class 6.1
HS Code 29154000

 Synthetic Route

 Customs

HS Code 29154000

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 Synonyms

Acetic acid,chloro
Monochloroethanoic acid
Acide chloracetique
2 chloroacetate
2-chloro acetic acid
Monochloressigsaeure
Chloracetic acid
Chloroethanoic acid
EINECS 201-178-4
MFCD00002683
chloroacetic acid
Chloroacetic acid,solid
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