The Journal of Organic Chemistry

Carboxylate protection for the synthesis of 4, 5-disubstituted 1-methylimidazoles

G Shapiro, B Gomez-Lor

Index: Journal of Organic Chemistry, , vol. 59, # 19 p. 5524 - 5526

Full Text: HTML

Citation Number: 28

Abstract

... (8) It has been shown that the dimethylamide ofN-methylimidazole- 2-carboxylic acid is readily deprotonated in the 5-position but the vigorous conditions of the amide hydrolysis-decarboxylation detract from this chemistry. Ngochindo, RIJ Chem. ... J. Org. Chem., Vol. 59, No. ...

 Related Synthetic Route
N,N-Dimethylformamide Structure

68-12-2

N,N-Dimethylfor...

4,5-dibromo-1-methylimidazole-2-carboxylic acid Structure

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4,5-dibromo-1-m...

~%

4-bromo-1-methyl-1H-imidazole-5-carboxaldehyde Structure

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methyl iodide Structure

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methyl iodide

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methylimidazole Structure

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methylimidazole

1,5-dimethylimidazole Structure

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1,5-dimethylimi...

N,N-Dimethylformamide Structure

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N,N-Dimethylfor...

4,5-dibromo-1-methylimidazole-2-carboxylic acid Structure

158585-80-9

4,5-dibromo-1-m...

~%

4-bromo-1-methyl-1H-imidazole-5-carboxaldehyde Structure

141524-74-5

4-bromo-1-methy...

1-Methylimidazole-4-carboxaldehyde Structure

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