A simple and versatile method for the synthesis of acetals from aldehydes and ketones using bismuth triflate

NM Leonard, MC Oswald, DA Freiberg…

Index: Leonard, Nicholas M.; Oswald, Matthew C.; Freiberg, Derek A.; Nattier, Bryce A.; Smith, Russell C.; Mohan, Ram S. Journal of Organic Chemistry, 2002 , vol. 67, # 15 p. 5202 - 5207

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Citation Number: 123

Abstract

Acetals are obtained in good yields by treatment of aldehydes and ketones with trialkyl orthoformate and the corresponding alcohol in the presence of 0.1 mol% Bi (OTf) 3⊙ 4H2O. A simple procedure for the formation of acetals of diaryl ketones has also been developed. The conversion of carbonyl compounds to the corresponding 1, 3-dioxolane using ethylene glycol is also catalyzed by Bi (OTf) 3⊙ 4H2O (1 mol%). Two methods, both of which avoid ...