Tethered bisubstrate derivatives as probes for mechanism and as inhibitors of aminoglycoside 3'-phosphotransferases

M Liu, J Haddad, E Azucena, LP Kotra…

Index: Kato; Arakawa; Ogawa; Suzumura Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 9 p. 3635 - 3643

Full Text: HTML

Citation Number: 36

Abstract

... Department of Chemistry and the Institute for Drug Design, Wayne State University, Detroit, Michigan 48202. J. Org. Chem. ... All other reagents were purchased from the Aldrich Chemical Co. ... The final volume for each assay mixture was 500 μL. ...

 Related Synthetic Route
((3aR,4R,6R,6aR)-2,2-dimethyl-6-(6-(pyrrolidin-1-yl)-9H-purin-9-yl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol Structure

109680-73-1

((3aR,4R,6R,6aR...

~0%

2',3'-O-Isopropylideneadenosine Structure

362-75-4

2',3'-O-Isoprop...

1-(9-((3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl)pyrrolidin-2-one Structure

109680-76-4

1-(9-((3aR,4R,6...

N-ethyl-N-(9-((3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl)acetamide Structure

109680-75-3

N-ethyl-N-(9-((...

~54%

2',3'-O-Isopropylideneadenosine Structure

362-75-4

2',3'-O-Isoprop...

((3aR,4R,6R,6aR)-6-(6-(diethylamino)-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol Structure

109680-71-9

((3aR,4R,6R,6aR...

~0%

2',3'-O-Isopropylideneadenosine Structure

362-75-4

2',3'-O-Isoprop...

N-ethyl-N-(9-((3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl)acetamide Structure

109680-75-3

N-ethyl-N-(9-((...

9-(2,3-Ο-isopropylidene-1β-D-ribofuranosyl)-6-(piperidin-1-yl)-9H-purine Structure

109680-74-2

9-(2,3-Ο-isopro...

~0%

2',3'-O-Isopropylideneadenosine Structure

362-75-4

2',3'-O-Isoprop...

5-((9-((3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl)amino)pentanoic acid Structure

109680-77-5

5-((9-((3aR,4R,...

N6,N6-dibenzyl-2',3'-O-isopropylideneadenosine Structure

109680-72-0

N6,N6-dibenzyl-...

~0%

2',3'-O-Isopropylideneadenosine Structure

362-75-4

2',3'-O-Isoprop...

2',3'-O-(1-Methylethylidene)-N-(phenylmethyl)adenosine Structure

78188-38-2

2',3'-O-(1-Meth...

2',3'-O-isopropylidene-N6,N6'-dimethyladenosine Structure

19083-21-7

2',3'-O-isoprop...

~0%

2',3'-O-Isopropylideneadenosine Structure

362-75-4

2',3'-O-Isoprop...

((3aR,4R,6R,6aR)-2,2-dimethyl-6-(6-(methylamino)-9H-purin-9-yl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol Structure

4566-77-2

((3aR,4R,6R,6aR...

N6,N6-dibenzyl-2',3'-O-isopropylideneadenosine Structure

109680-72-0

N6,N6-dibenzyl-...

~14%

2',3'-O-Isopropylideneadenosine Structure

362-75-4

2',3'-O-Isoprop...

2',3'-O-(1-Methylethylidene)-N-(phenylmethyl)adenosine Structure

78188-38-2

2',3'-O-(1-Meth...


Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved