Potential tumor-or organ-imaging agents. 26. Polyiodinated 2-substituted triacylglycerols as hepatographic agents

…, SW Schwendner, RE Counsell

Index: Weichert; Longino; Schwendner; Counsell Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1674 - 1682

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Citation Number: 18

Abstract

A series of w-(3-amino-2, 4, 6-triiodophenyl) alkanoic acids and the corresponding 1, 3- dipalmitoylglycerol 2-[~-(3-amino-2, 4, 6-triiodophenyl) alkanoates] were synthesized, radioiodinated with iodine-125, and evaluated for their ability to selectively localize in the liver for potential use as hepatographic imaging agenta. Acid analogues Id and le afforded relatively high levels of radioactivity in the liver (45 and 49% injected dose) 5 min after ...

~64%

~85%

~62%

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