Organic letters

Iron-catalyzed cross-coupling of alkyl sulfonates with arylzinc reagents

S Ito, Y Fujiwara, E Nakamura, M Nakamura

Index: Ito, Shingo; Fujiwara, Yu-Ichi; Nakamura, Eiichi; Nakamura, Masaharu Organic Letters, 2009 , vol. 11, # 19 p. 4306 - 4309

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Citation Number: 48

Abstract

Iron-catalyzed cross-coupling reactions of primary and secondary alkyl sulfonates with arylzinc reagents proceed smoothly in the presence of excess TMEDA and a concomitant magnesium salt. The arylzinc reagents are prepared from the corresponding aryllithium or magnesium reagents with ZnI2. The in situ formation of alkyl iodides and consecutive rapid cross-coupling avoids discrete preparation of the unstable secondary alkyl halides and ...