Synthesis of Chromones through LiOtBu/Air??Mediated Oxidation and Regioselective Cyclization of o??Hydroxyphenyl Propargyl Carbinols

…, C Wan, Q Wang, B Zhang, L Gao, Z Zha…

Index: Zhang, Shuai; Wan, Changfeng; Wang, Qiang; Zhang, Baiqun; Gao, Lingfeng; Zha, Zhenggen; Wang, Zhiyong European Journal of Organic Chemistry, 2013 , # 11 p. 2080 - 2083

Full Text: HTML

Citation Number: 8

Abstract

Abstract A cascade oxidative cyclization reaction for the synthesis of chromone derivatives was developed by using LiOtBu as a mediator and air as an oxidant. The reaction was carried out without the assistance of a transition metal under mild conditions to afford the chromones in good yields with high regioselectivities.

 Related Synthetic Route
N/A Structure

1262020-27-8

N/A

~61%

4H-1-Benzopyran-4-one,6-chloro-2-phenyl- Structure

10420-73-2

4H-1-Benzopyran...

N/A Structure

133503-46-5

N/A

~78%

6-Methoxyflavone Structure

26964-24-9

6-Methoxyflavone

Mequinol Structure

150-76-5

Mequinol

~%

6-Methoxyflavone Structure

26964-24-9

6-Methoxyflavone

2-Hydroxy-5-methoxybenzaldehyde Structure

672-13-9

2-Hydroxy-5-met...

Phenylacetylene Structure

536-74-3

Phenylacetylene

~%

6-Methoxyflavone Structure

26964-24-9

6-Methoxyflavone

Ethanol Structure

64-17-5

Ethanol

4-tert-Butylphenol Structure

98-54-4

4-tert-Butylphenol

~%

5-Tert-butyl-2-hydroxybenzaldehyde Structure

2725-53-3

5-Tert-butyl-2-...

Phenol Structure

108-95-2

Phenol

~%

2-Benzylidene-3(2H)-benzofuranone Structure

582-04-7

2-Benzylidene-3...

Salicylaldehyde Structure

90-02-8

Salicylaldehyde

Phenylacetylene Structure

536-74-3

Phenylacetylene

~%

2-Benzylidene-3(2H)-benzofuranone Structure

582-04-7

2-Benzylidene-3...

1-(2-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-yn-1-ol Structure

109600-56-8

1-(2-hydroxyphe...

~80%

4'-Methoxyflavone Structure

4143-74-2

4'-Methoxyflavone

Phenol Structure

108-95-2

Phenol

~%

4'-Methoxyflavone Structure

4143-74-2

4'-Methoxyflavone

Salicylaldehyde Structure

90-02-8

Salicylaldehyde

4-Ethynylanisole Structure

768-60-5

4-Ethynylanisole

~%

4'-Methoxyflavone Structure

4143-74-2

4'-Methoxyflavone

1-(2-hydroxyphenyl)-3-(p-tolyl)prop-2-yn-1-ol Structure

125349-02-2

1-(2-hydroxyphe...

~73%

4H-1-BENZOPYRAN-4-ONE, 2-(4-METHYLPHENYL)- Structure

41255-30-5

4H-1-BENZOPYRAN...

Phenol Structure

108-95-2

Phenol

~%

4H-1-BENZOPYRAN-4-ONE, 2-(4-METHYLPHENYL)- Structure

41255-30-5

4H-1-BENZOPYRAN...

Salicylaldehyde Structure

90-02-8

Salicylaldehyde

4-Ethynyltoluene Structure

766-97-2

4-Ethynyltoluene

~%

4H-1-BENZOPYRAN-4-ONE, 2-(4-METHYLPHENYL)- Structure

41255-30-5

4H-1-BENZOPYRAN...


Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved