The Journal of organic chemistry

Development of trityl-based photolabile hydroxyl protecting groups

L Zhou, H Yang, P Wang

Index: Zhou, Lei; Yang, Haishen; Wang, Pengfei Journal of Organic Chemistry, 2011 , vol. 76, # 15 p. 5873 - 5881

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Citation Number: 17

Abstract

A series of trityl-based photolabile hydroxyl protecting groups have been examined. These PPGs evolve from the traditional acid-labile trityl protecting group with proper electron- donating substituents. Structure–reactivity relationships have been explored. A m- dimethylamino group is crucial to achieve high photochemical deprotection efficiency. The o- hydroxyl group in 8 greatly improves the yield of the photochemical deprotection reaction, ...