1, 1, 1-Trichloro-4, 4-diethoxy-3-buten-2-one and its Trichloroacetylacetate Derivatives: Synthesis and Applications in Regiospecific Preparation of Azoles

…, AP Sinhorin, W Cunico, N Zanatta, HG Bonacorso…

Index: Martins, Marcos A. P.; Pereira, Claudio M. P.; Zimmermann, Nilo E. K.; Moura, Sidnei; Sinhorin, Adilson P.; Cunico, Wilson; Zanatta, Nilo; Bonacorso, Helio G.; Flores, Alex C. F. Synthesis, 2003 , # 15 p. 2353 - 2357

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Citation Number: 24

Abstract

Abstract The synthesis of 1, 1, 1-trichloro-4, 4-diethoxy-3-buten-2-one and three trichloroacetylacetate derivatives from the acylation reaction of respective trialkyl orthoacetates and orthopropionates with trichloroacetyl chloride in good yields, is reported. The title compounds were used for the regiospecific preparation of two isoxazoles and five pyrazoles in the cyclocondensation with hydroxylamine and hydrazines, respectively. The ...