Synthesis of Novel HMG??CoA Reductase Inhibitors, I. Naphthalene Analogs of Mevinolin

…, L Poppe, G Hornyánszky, P Kolonits…

Index: Novak, Lajos; Rohaly, Janos; Poppe, Laszlo; Hornyanszky, Gabor; Kolonits, Pal; et al. Liebigs Annalen der Chemie, 1992 , # 2 p. 145 - 158

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Citation Number: 8

Abstract

Abstract The title compounds 2 and their corresponding (6 S) epimers 18 are prepared in several steps by starting with chiral formyl ester 5, and α-tetralones 10:(1) coupling reaction with the ylide generated from 11 to yield unsaturated ester 13,(2) reduction to the ...