Bioorganic & medicinal chemistry letters

A novel series of urea-based peptidomimetic calpain inhibitors

ML Sanders, IO Donkor

Index: Sanders, M. Lee; Donkor, Isaac O. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 7 p. 1965 - 1968

Full Text: HTML

Citation Number: 10

Abstract

A series of peptide aldehyde derivatives in which the P2 chiral carbon has been replaced with nitrogen were synthesized as urea-based peptidomimetic inhibitors of μ-calpain. The compounds mirrored the general SAR of peptidyl aldehyde calpain inhibitors but displayed greater selectivity for μ-calpain over cathepsin B.