Tetrahedron

Investigations on the stereospecificity of peptide active phenyl ester formation and coupling

J Kovacs, L Kisfaludy, MQ Ceprini, RH Johnson

Index: Kovacs,J. et al. Tetrahedron, 1969 , vol. 25, p. 2555 - 2573

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Citation Number: 30

Abstract

Phenolic active esters were investigated for stereospecificity during their formation and subsequent coupling. The different esters of Z Gly Phe OH, Z Gly Gly Phe OH and Bz Leu OH were prepared either by:(a) the backing-off procedure,(b) the usual DCC method,(c) the reverse DCC procedure, or (d) by use of a crystalline “complex” consisting of the isourea derivative “A” and 2 PCPOH. In the preparation of active esters by methods (b) ...